Toxicity is usually investigated using a set of standardized animal-based studies which,
unfortunately, fail to detect all compounds that induce human adverse events and do not …

Toxicogenomics has evolved into a useful technique for providing greater mechanistic
insights into adverse effects that will spur the development of novel approaches for …

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic
and professional researchers employing toxicogenomic methods with respect to animal …

Traditional toxicity testing using animal models is slow, low capacity, expensive and
assesses a limited number of endpoints. Such approaches are inadequate to deal with the …

Basic research is critical to toxicology in that it contributes to the understanding of how
biological systems respond to perturbation (mechanistic studies) and to advances in toxicity …

With the emergence of microarray and other genomic technologies came anticipation that
monitoring thousands of analytes in parallel would improve efficiencies in screening drug …

Toxicology is an observational science that investigates cellular and animal responses to a
chemical treatment through various endpoint-specific assays (eg, developmental toxicity …

The field of toxicogenomics has been advancing during the past decade or so since its
origin. Most pharmaceutical companies are using it in one or more ways to improve their …

The toxicology community is in the midst of a paradigm shift, moving from high-dose testing
in animals with extrapolation to expected responses in humans to an in vitro approach …

High throughput screening (HTS) and functional genomics (toxicogenomics) have opened
new avenues in toxicity testing. Their advantages include the potential for developing short …