Background Radicular pain is a common and debilitating clinical pain condition. To date, the
mechanisms of radicular pain remain unclear, partly because of the lack of suitable …

BACKGROUND: Perioperative fentanyl has been reported to induce hyperalgesia and
increase postoperative pain. In this study, we tried to investigate behavioral hyperalgesia …

Background and Objectives: Inflammatory responses in the lumbar dorsal root ganglion
(DRG) play a key role in pathologic pain states. Systemic administration of a common anti …

BACKGROUND: Intrathecal (IT) administration of the α-2 adrenoceptor agonist, clonidine,
produces significant analgesic effects. Although several mechanisms underlying clonidine …

BACKGROUND: Injury of a spinal nerve or dorsal root ganglion (DRG) during selective
spinal nerve blocks is a potentially serious complication that has not been adequately …

Background. Quantitative sensory testing (QST) has been used to predict the outcome of
epidural steroid injections in lumbosacral radicular pain and has the potential to be an …

Background Discogenic low back pain has been shown to develop into chronic intractable
pain due to an unknown pathogenesis. To study the mechanism of discogenic pain, we …

Background Basic data are lacking regarding the efficacy and mechanisms of action of
corticosteroids in neuropathic pain. Because recent studies indicate that spinal glial …

BACKGROUND: Spinal N-methyl d-aspartate receptors play an important role in the
pathogenesis of neuropathic pain, and administration of N-methyl d-aspartate receptor …

Background Painful peripheral nerve injury results in disordered sensory neuron function
that contributes to the pathogenesis of neuropathic pain. However, the relative roles of …