Intratumoral heterogeneity and clonal evolution induced by HPV integration

K Akagi, DE Symer, M Mahmoud, B Jiang, S Goodwin… - Cancer discovery, 2023 - AACR
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …

Human papillomavirus integration strictly correlates with global genome instability in head and neck cancer

B Labarge, M Hennessy, L Zhang, D Goldrich… - Molecular Cancer …, 2022 - AACR
Human papillomavirus (HPV)-positive head and neck cancers, predominantly
oropharyngeal squamous cell carcinoma (OPSCC), exhibit epidemiologic, clinical, and …

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

K Akagi, J Li, TR Broutian, H Padilla-Nash… - Genome …, 2014 - genome.cshlp.org
Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

Dangerous liaisons: long-term replication with an extrachromosomal HPV genome

A Warburton, AN Della Fera, AA McBride - Viruses, 2021 - mdpi.com
Papillomaviruses cause persistent, and usually self-limiting, infections in the mucosal and
cutaneous surfaces of the host epithelium. However, in some cases, infection with an …

Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers

DE Symer, K Akagi, HM Geiger, Y Song, G Li… - Genome …, 2022 - genome.cshlp.org
Human papillomavirus (HPV) causes 5% of all cancers and frequently integrates into host
chromosomes. The HPV oncoproteins E6 and E7 are necessary but insufficient for cancer …

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

IJ Groves, N Coleman - The Journal of pathology, 2018 - Wiley Online Library
Human papillomavirus (HPV) infection is associated with∼ 5% of all human cancers,
including a range of squamous cell carcinomas. Persistent infection by high‐risk HPVs …

Characterization of HPV and host genome interactions in primary head and neck cancers

M Parfenov, CS Pedamallu… - Proceedings of the …, 2014 - National Acad Sciences
Previous studies have established that a subset of head and neck tumors contains human
papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display …

Human papillomavirus genome integration and head and neck cancer

LM Pinatti, HM Walline… - Journal of dental …, 2018 - journals.sagepub.com
We conducted a critical review of human papillomavirus (HPV) integration into the host
genome in oral/oropharyngeal cancer, reviewed the literature for HPV-induced cancers, and …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …

Recombination-dependent oligomerization of human papillomavirus genomes upon transient DNA replication

M Orav, L Henno, H Isok-Paas, J Geimanen… - Journal of …, 2013 - Am Soc Microbiol
We describe the extensive and progressive oligomerization of human papillomavirus (HPV)
genomes after transfection into the U2OS cell line. The HPV genomic oligomers are …