The resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) is an emerging
public health threat. Resistance to these drugs is associated with point mutations in the …

The key codons of dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr)
genes implicated in sulfadoxine-pyrimethamine (SP) resistance were determined by allele …

As resistance to chloroquine spreads in sub-Saharan Africa, pyrimethamine plus
sulfadoxine (PSD) is increasingly used as a first-line treatment for falciparum malaria …

To assess the relationship between mutations in Plasmodium falciparum dihydrofolate
reductase (DHFR) and dihydropteroate synthase (DHPS) and clinical pyrimethamine …

Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium
falciparum have not been implemented because of the genetic and statistical complexity of …

To assess sulfadoxine and pyrimethamine resistance (SPR), we describe here the
dihydropteroate synthetase (DHPS) mutations among the Plasmodium falciparum isolates in …

Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) is due to mutations in
the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhfr) genes. Large-scale …

Recent studies indicated that sensitive parasites could increase in frequency in a population
when drugs are removed, suggesting that the life span of affordable antimalarial drugs could …

Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a
number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase …

Molecular investigations performed following the emergence of sulfadoxine-pyrimethamine
(SP) resistance in Plasmodium falciparum have allowed the identification of the …