The risk of leukemia was evaluated in 9,170 2-or-more-year survivors of childhood cancer in
the 13 institutions of the Late Effects Study Group. Secondary leukemia occurred in 22 …

[en] The study of long-term effects of therapy for childhood cancer is important for several
reasons. An increasing proportion of children are now cured of their cancer and can expect …

Background Individuals who had cancer in childhood are at higher risk of developing bone
cancer than any other type of second primary cancer. Purpose Using the population-based …

A new malignancy was diagnosed in 19 of 414 long‐term survivors of cancer in childhood.
All but two lesions were attributable to prior radiotherapy; eight were successfully treated …

The carcinogenic potential of anticancer drugs is discussed in the light of selected basic
principles of chemical carcinogenesis. Anticancer drugs which act by alkylation and/or by …

The objectives of our study were to quantify risks for developing new malignancies among
childhood cancer survivors, identify links between particular types of first and subsequent …

The median latency of 2 degrees MDS/AL is 4 to 5 years. A high percentage of patients with
2 degrees MDS/AL convert to 2 degrees AL. Survival of either is less than 1 year. A …

The leukemogenic potential of alkylating agents has been known for many years and almost
all alkylating agents in clinical use have been shown to increase the risk of leukemia. With …

An investigation of 749 deaths occurring among 4082 patients surviving at least five years
after the diagnosis of childhood cancer in Britain before 1971 has been undertaken. Of the …

Background. Effective forms of treatment for acute lymphoblastic leukemia (ALL) in
childhood now result in survival rates above 70 percent at five years, but the treatments are …