BACkGROunD Primaquine is currently the only medicine for treating relapses of
Plasmodium vivax and P. ovale malaria, due to its specific activity against malaria …

Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely
originate from dormant liver forms called hypnozoites. We do not systematically attack that …

Primaquine is the only available antimalarial drug that kills dormant liver stages of
Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse …

Malaria elimination will be possible only with serious attempts to address asymptomatic
infection and chronic infection by both Plasmodium falciparum and Plasmodium vivax …

Plasmodium vivax malaria continues to cause a significant burden of disease in the Asia-
Pacific, the Horn of Africa, and the Americas. In addition to schizontocidal treatment, the 8 …

Background Primaquine is used to prevent Plasmodium vivax relapse; however, it is not
implemented in many malaria-endemic countries, including Cambodia, for fear of …

Background Primaquine is the only drug consistently effective against mature gametocytes
of Plasmodium falciparum. The transmission blocking dose of primaquine previously …

Background Primaquine is currently the only medication used for radical cure of
Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6 …

Recent successes in malaria control have put malaria eradication back on the public health
agenda. A significant obstacle to malaria elimination in Asia is the large burden of …

Background The incidence of malaria in the Americas has decreased markedly in recent
years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have …