The safety of lentiviral vectors for clinical applications is still a major concern. The gag-pol
expression plasmids and the lentiviral vectors used in previous studies contain homologous …

The human immunodeficiency virus (HIV) genome is AU rich, and this imparts a codon bias
that is quite different from the one used by human genes. The codon usage is particularly …

Vectors derived from human immunodeficiency virus (HIV) are highly efficient vehicles for in
vivo gene delivery. However, their biosafety is of major concern. Here we exploit the …

Lentiviruses infect both dividing and nondividing cells. In this study we characterized a
lentiviral vector system consisting of a packaging vector (pHP) and a transducing vector …

Lentiviral vectors are attractive candidates for gene therapy because of their ability to
integrate into nondividing cells. To date, conventional HIV-1-based vectors can be produced …

In contrast to oncoviruses, lentiviruses do not require target cell division for integration into
the host genome. Lentiviral vectors can therefore expand the spectrum of target cells …

Background Lentiviral vectors allow gene transfer into non‐dividing cells. Further
development of these vector systems requires stable packaging cell lines that enable …

Human immunodeficiency virus type 1 (HIV-1)–based vectors are currently made by
transient transfection, or using packaging cell lines in which expression of HIV-1 Gag and …

Control of the worldwide AIDS pandemic may require not only preventive but also
therapeutic immunization strategies. To meet this challenge, the next generation of human …

We have devised a novel approach for producing simian immunodeficiency virus (SIV)
strains and, potentially, human immunodeficiency virus type 1 (HIV-1) strains that are limited …