Lentiviral vectors based on HIV-1, HIV-2, or SIV have the ability to transduce dividing and
non-dividing T cells, dendritic cells, hematopoietic stem cells and macrophages, which are …

Gene therapy against HIV infection should involve vector-mediated delivery of anti-HIV
therapeutic genes into T-lymphocytes and macrophages or, alternatively, hematopoietic …

Lentiviruses are potentially advantageous compared to oncoretroviruses as gene transfer
agents because they can infect nondividing cells. We demonstrate here that human …

Live, attenuated viruses have been the most successful vaccines in monkey models of
human immunodeficiency virus type 1 (HIV-1) infection. However, there are several safety …

In this report, we evaluated the efficiency of stable gene transfer into established CD8+
human tumor antigen-specific cytotoxic T cell (CTL) lines and peripheral blood lymphocytes …

Recombinant rabies virus (RV) vaccine strain-based vectors have been successfully
developed as vaccines against other viral diseases (JP McGettigan et al., J. Virol. 75: 4430 …

ABSTRACT A synthetic gene consisting of the reverse transcriptase (RT) and integrase (IN)
domains of human immunodeficiency virus type 1 (HIV-1) pol was constructed using codons …

The ability of lentiviral vectors to transduce and stably integrate their genomes into non-
dividing cells was the major reason for the development of the HIV-1 based vector gene …

Gene transfer using lentiviral vectors has been recently shown to be enhanced with cis-
acting elements in a cell-type-dependent manner in vivo. For this reason, the study reported …

CD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and
represent one of the main sources of virus replication. Gene therapy strategies are being …