We have previously reported the selective amplification of several rat striatal cDNA
sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled …

We have used the polymerase chain reaction technique to selectively amplify guanine
nucleotide-binding regulatory protein (G protein)-coupled receptor cDNA sequences from rat …

The human A3 adenosine receptor was cloned from a striatal cDNA library using a probe
derived from the homologous rat sequence. The cDNA encodes a protein of 318 amino …

A cDNA encoding a G protein-coupled receptor of unknown ligand specificity was isolated
from a human hippocampal cDNA library by virtue of the high degree of structural homology …

* Address correspondence to: PJM van Galen, NIH/NIDDK, Building 8A, Room B1A-17,
Bethesda, MD 20892; telephone 301-496-9024; fax 301-402-0008. Medicinal Research …

The A1 adenosine receptor is a member of the seven-transmembrane G protein-coupled,
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

SUMMARY A novel adenosine receptor, the A 3 receptor, has recently been cloned. We
have systematically investigated the hitherto largely unexplored structure-activity …

A new radiolabeled adenosine receptor agonist, 2‐[p‐(2‐carboxyethyl) phenethylamino]‐
5′‐. N‐ethylcarboxamidoadenosine (CGS 21680), apparently specific for high‐affinity …

To provide new insights into ligand/A1 adenosine receptor(A1 AR) interactions, site-directed
mutagenesis was used to test the role of several residues in the first four …