The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

The influence of the adenosine A2A receptor on the A1 receptor was examined in rat striatal
nerve terminals, a model for other cells in which these receptors are coexpressed …

Adenosine receptors represent a family of G‐protein coupled receptors that are ubiquitously
expressed in a wide variety of tissues. This family contains four receptor subtypes: A1 and …

The adenosine (ADO) receptor in NIH 3T3 fibroblasts was characterized using a series of
adenosine agonists and selected xanthine and non-xanthine antagonists. The ADO receptor …

Numerous investigations indicate a role for adenosine in neurotransmission or
neuromodulation actions which appear to be mediated in brain by at least two types of …

A human brain hippocampus cDNA library was screened by hybridization with a dog Al
adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 …

The cDNA of an unidentified recently cloned G protein-coupled receptor, RDC8, has been
expressed in Y1 adrenal cells, in dog thyrocytes in primary culture and in Xenopus oocytes …

N6-Cyclohexyl [3H] adenosine ([3H] CHA) and 1, 3-diethyl-8-[3H] phenylxanthine ([3H] DPX)
to bind to adenosine receptors in brain membranes. The agonist [3H] CHA has high affinity …

Receptor antagonists can be classified as neutral antagonists or antagonists with inverse
agonist activity based on their effectiveness to reduce the spontaneous agonist-independent …

Evaluation of adenosine A2 receptor function in the mammalian CNS has been impeded by
the lack ofhighly selective A2 receptor agonists. The present investigations describe the …