The immune system has evolved to defend the host against infectious disease. Here,
Duncan Adams outlines the historic developments that have led to our current …

An infectious agent contributes to the induction of autoimmunity in two ways. First, it provides
a cognate, antigen-specific signal by molecular mimicry or by mobilizing endogenous …

The relationship between infections and autoimmunity as well as the risk of infections due to
antirheumatic agents, including corticosteroids, immunosuppressants and biologics, are …

Autoimmune diseases are a spectrum of clinical inflammatory syndromes with circulating
autoantibodies. Autoimmune diseases affect millions of patients worldwide with enormous …

The year of preparation of The Autoimmune Diseases 11 (1991) is the 40th anniversary of
the first cited adjectival description of “autoimmune,” in reference to hemolytic anemia …

The concept of “original antigenic sin” was first proposed by Thomas Francis, Jr. in 1960.
This phenomenon has the potential to rewrite what we understand about how the immune …

The expanding world of autoimmunity: Trends in Immunology Skip to Main Content
Advertisement Trends in Immunology This journal offers authors two options (open access or …

Heterologous immunity is a common phenomenon present in all infections. Most of the time
it is beneficial, mediating protective immunity, but in some individuals that have the wrong …

The causes of autoimmune diseases have yet to be fully elucidated. Autoantibodies,
autoreactive T cell responses, the presence of a predisposing major histocompatibility …

Autoimmunity is a significant health concern with diseases such as type 1 diabetes,
rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, drastically …