[HTML][HTML] Pseudomonas aeruginosa's adaptive trajectory: diverse origins, convergent paths

TB Taylor, MJ Shepherd, JS Horton - Trends in Microbiology, 2023 - cell.com
Does genetic background contribute to populations following the same or divergent adaptive
trajectories? A recent study by Filipow et al. evolved multiple genetically distinct …

Antibiotic resistance in Pseudomonas aeruginosa and adaptation to complex dynamic environments

LM Sommer, HK Johansen, S Molin - Microbial genomics, 2020 - microbiologyresearch.org
Antibiotic resistance has become a serious threat to human health (WHO Antibacterial
Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development …

[HTML][HTML] Genomics of Adaptation during Experimental Evolution of the Opportunistic Pathogen Pseudomonas aeruginosa

A Wong, N Rodrigue, R Kassen - 2012 - journals.plos.org
Adaptation is likely to be an important determinant of the success of many pathogens, for
example when colonizing a new host species, when challenged by antibiotic treatment, or in …

Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions

A Schick, R Kassen - … of the National Academy of Sciences, 2018 - National Acad Sciences
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

[HTML][HTML] Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone

C López-Causapé, LM Sommer, G Cabot, R Rubio… - Scientific reports, 2017 - nature.com
Emergence of epidemic clones and antibiotic resistance development compromises the
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections …

[HTML][HTML] Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis

LJ Sherrard, AS Tai, BA Wee, KA Ramsay, TJ Kidd… - PLoS …, 2017 - journals.plos.org
A Pseudomonas aeruginosa AUST-02 strain sub-type (M3L7) has been identified in
Australia, infects the lungs of some people with cystic fibrosis and is associated with …

The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection

J Vanderwoude, S Azimi, TD Read, SP Diggle - Mbio, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …

[HTML][HTML] Pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity

MV Grosso-Becerra, C Santos-Medellín… - BMC genomics, 2014 - Springer
Background Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence
of hospital infections that represents a threat to immune compromised patients. Genomic …

Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model

S Irvine, B Bunk, HK Bayes, C Spröer… - Microbial …, 2019 - microbiologyresearch.org
Phenotypic change is a hallmark of bacterial adaptation during chronic infection. In the case
of chronic Pseudomonas aeruginosa lung infection in patients with cystic fibrosis, well …

[HTML][HTML] Positive Signature-Tagged Mutagenesis in Pseudomonas aeruginosa: Tracking Patho-Adaptive Mutations Promoting Airways Chronic Infection

I Bianconi, A Milani, C Cigana, M Paroni… - PLoS …, 2011 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa can establish life-long chronic
infections in the airways of cystic fibrosis (CF) patients. Persistent lifestyle is established with …