Tetrandrine is an alkaloid obtained from the root of a medicinal herb which is employed in
China as a treatment for silicosis. One proposed mechanism for the development of silica …

Tetrandnne is a bisbenzylisoquinoline alkaloid which has been shown to exhibit antifibrotic
activity against silicosis. Tetrandrine is characterized by its strong binding to alveolar …

Tetrandrine, an anti-inflammatory immunosuppressive bisbenzylisoquinoline alkaloid of
Chinese herbal origin, is widely used to treat silicosis and interferes with the regulation of …

Silicosis is a fatal pulmonary disease caused by the inhalation of silica dust, and
characterized by inflammation and fibrosis of the lung, with no effective treatment to date …

Pulmonary fibrosis is a disease in which lung tissues become fibrous and thereby causes
severe respiratory disturbances. Various stimuli induce infiltration of macrophages to the …

Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf
extract in the prevention of lung injury induced by silica particles. Method Lung injury was …

Alveolar macrophages are believed to induce oxidative stress via reactive oxygen species
(ROS) when silica particles are inhaled. This process can contribute to the pathogenesis of …

Inhalation of silicon dioxide (SD) results in pulmonary inflammatory responses and fibrosis.
Isorhynchophylline (Isorhy) is the main alkaloid in the traditional Chinese herb Tripterygium …

The present study examined the effect of ambroxol on free radical production, granule
enzyme release, and cell death in silica-activated rat alveolar macrophages. The action of …

This study aims to explore the molecular mechanism of tetrandrine (Tet) in alleviating
pulmonary inflammation and fibrosis induced by silica (SiO2) from the perspective of …