Male sexual differentiation involves a cascade of events initiated by the presence on the Y
chromosome of the SRY gene, which causes the indifferent gonad to develop into a testis …

In humans, activation of genes in the testis-determining pathway at 7–8 weeks gestation
causes the bipotential gonad to develop as a testis. The first morphologically recognisable …

Forty-six XX disorder of sex development is an uncommon medical condition observed at
times during the evaluation of a man's fertility. The following is a case series and literature …

Primary amenorrhea due to 46, XY disorders of sexual development (DSD) is complex with
the involvement of several genes. Karyotyping of such patients is important as they may …

Disorders of sex development (DSD) are congenital abnormalities as an atypical
development process in either gonadal or chromosomal structure. It is the cause of the …

Abstract 46, XY complete gonadal dysgenesis (Swyer syndrome) is a rare cause of disorder
of sexual development. This syndrome is caused by a defect in the determination of sex …

Mixed gonadal dysgenesis (MGD) includes a group of heterogeneous conditions consisting
of a dysgenetic testis with a streak gonad. MGD is probably due to a disturbance in testicular …

Chromosomal sex is normally determined at fertilization. The zygote has either an XX or an
XY chromosome constitution that is maintained by mitosis in all cell types as the embryo …

Sex in mammals is genetically determined and is defined at the cellular level by sex
chromosome complement (XY males and XX females). The Y chromosome–linked gene sex …

Abstract Introduction and Objectives: Testicular feminization is the syndrome when a male,
genetically XY, because of various abnormalities of the X chromosome, is resistant to the …