Molecular Characterization of the Mg2+-Responsive PhoP-PhoQ Regulon in Salmonella enterica

S Lejona, A Aguirre, ML Cabeza, EG Véscovi… - Journal of …, 2003 - Am Soc Microbiol
ABSTRACT The PhoP/PhoQ two-component system controls the extracellular magnesium
deprivation response in Salmonella enterica. In addition, several virulence-associated …

Novel mode of transcription regulation of divergently overlapping promoters by PhoP, the regulator of two‐component system sensing external magnesium availability

K Yamamoto, H Ogasawara, N Fujita… - Molecular …, 2002 - Wiley Online Library
PhoP is a response regulator of the PhoQ‐PhoP two‐component system controlling a set of
the Mg (II)‐response genes in Escherichia coli. Here we demonstrate the mode of …

Molecular Characterization of the PhoP-PhoQ Two-Component System in Escherichia coli K-12: Identification of Extracellular Mg2+-Responsive Promoters

A Kato, H Tanabe, R Utsumi - Journal of bacteriology, 1999 - Am Soc Microbiol
We identified Mg2+-responsive promoters of the phoPQ, mgtA, and mgrB genes of
Escherichia coli K-12 by S1 nuclease analysis. Expression of these genes was induced by …

Evolution of a Bacterial Regulon Controlling Virulence and Mg2+ Homeostasis

JC Perez, D Shin, I Zwir, T Latifi, TJ Hadley… - PLoS …, 2009 - journals.plos.org
Related organisms typically rely on orthologous regulatory proteins to respond to a given
signal. However, the extent to which (or even if) the targets of shared regulatory proteins are …

Signal-dependent binding of the response regulators PhoP and PmrA to their target promoters in vivo

D Shin, EA Groisman - Journal of Biological Chemistry, 2005 - ASBMB
Low Mg 2+ promotes phosphorylation of the response regulators PhoP and PmrA and
transcription of their activated genes in Salmonella enterica. Using chromatin …

The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and …

SL Gellatly, B Needham, L Madera, MS Trent… - Infection and …, 2012 - Am Soc Microbiol
The adaptation of Pseudomonas aeruginosa to its environment, including the host, is tightly
controlled by its network of regulatory systems. The two-component regulatory system …

A Two-Component Regulatory System Interconnects Resistance to Polymyxins, Aminoglycosides, Fluoroquinolones, and β-Lactams in Pseudomonas aeruginosa

C Muller, P Plésiat, K Jeannot - Antimicrobial agents and …, 2011 - Am Soc Microbiol
Constitutive overexpression of the active efflux system MexXY/OprM is a major cause of
resistance to aminoglycosides, fluoroquinolones, and cefepime in clinical strains of …

Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of …

WJ Gooderham, M Bains, JB McPhee… - Journal of …, 2008 - Am Soc Microbiol
Pseudomonas aeruginosa is an important opportunistic pathogen that causes infections that
can be extremely difficult to treat due to its high intrinsic antibiotic resistance and broad …

Identification of Novel phoP-phoQ Regulated Genes that Contribute to Polymyxin B Tolerance in Pseudomonas aeruginosa

B Yang, C Liu, X Pan, W Fu, Z Fan, Y Jin, F Bai… - Microorganisms, 2021 - mdpi.com
Polymyxin B and E (colistin) are the last resorts to treat multidrug-resistant Gram-negative
pathogens. Pseudomonas aeruginosa is intrinsically resistant to a variety of antibiotics. The …

The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development

H Sakhtah, L Koyama, Y Zhang… - Proceedings of the …, 2016 - National Acad Sciences
Redox-cycling compounds, including endogenously produced phenazine antibiotics, induce
expression of the efflux pump MexGHI-OpmD in the opportunistic pathogen Pseudomonas …