Rationally designed multivalent aptamers targeting cell surface for biomedical applications

M Lin, J Zhang, H Wan, C Yan, F Xia - ACS Applied Materials & …, 2020 - ACS Publications
Specific interactions between ligands and receptors on cell surface play an important role in
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …

Functional aptamer-embedded nanomaterials for diagnostics and therapeutics

S Xie, L Ai, C Cui, T Fu, X Cheng, F Qu… - ACS applied materials & …, 2021 - ACS Publications
In the past decades, various nanomaterials with unique properties have been explored for
bioapplications. Meanwhile, aptamers, generated from the systematic evolution of ligands by …

[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging

M Liu, L Wang, Y Lo, SCC Shiu, AB Kinghorn… - Cells, 2022 - mdpi.com
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …

Multivalent aptamer approach: designs, strategies, and applications

Z Wang, X Yang, NZ Lee, X Cao - Micromachines, 2022 - mdpi.com
Aptamers are short and single-stranded DNA or RNA molecules with highly programmable
structures that give them the ability to interact specifically with a large variety of targets …

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

Aptamer‐assembled nanomaterials for biosensing and biomedical applications

RM Kong, XB Zhang, Z Chen, W Tan - Small, 2011 - Wiley Online Library
Aptamers represent a class of single‐stranded DNA or RNA oligonucleotides that play
important roles in biosensing and biomedical applications. However, aptamers can gain …

Bioapplications of cell-SELEX-generated aptamers in cancer diagnostics, therapeutics, theranostics and biomarker discovery: a comprehensive review

X Pang, C Cui, S Wan, Y Jiang, L Zhang, L Xia, L Li… - Cancers, 2018 - mdpi.com
Currently, functional single-stranded oligonucleotide probes, termed aptamers, generated
by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment …

Aptamer-functionalized nanomaterials for biological applications

Q Ren, L Ga, Z Lu, J Ai, T Wang - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Aptamers have attracted the attention of many researchers because of their high stability,
high affinity and high selectivity. Over the past decades, considerable intensive exploration …

Recent progress in aptamer discoveries and modifications for therapeutic applications

S Ni, Z Zhuo, Y Pan, Y Yu, F Li, J Liu… - … Applied Materials & …, 2020 - ACS Publications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …

The therapeutic potential of cell-internalizing aptamers

J Zhou, JJ Rossi - Current topics in medicinal chemistry, 2009 - ingentaconnect.com
Aptamers that are evolved by the SELEX procedure (Systematic Evolution of Ligands by
Exponential enrichment) can specifically recognize and tightly bind their cognate targets by …