Rationally designed multivalent aptamers targeting cell surface for biomedical applications
Specific interactions between ligands and receptors on cell surface play an important role in
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …
Functional aptamer-embedded nanomaterials for diagnostics and therapeutics
In the past decades, various nanomaterials with unique properties have been explored for
bioapplications. Meanwhile, aptamers, generated from the systematic evolution of ligands by …
bioapplications. Meanwhile, aptamers, generated from the systematic evolution of ligands by …
[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …
for a plethora of therapeutic and diagnostic applications. Such applications include drug …
Multivalent aptamer approach: designs, strategies, and applications
Z Wang, X Yang, NZ Lee, X Cao - Micromachines, 2022 - mdpi.com
Aptamers are short and single-stranded DNA or RNA molecules with highly programmable
structures that give them the ability to interact specifically with a large variety of targets …
structures that give them the ability to interact specifically with a large variety of targets …
Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment
S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
Aptamer‐assembled nanomaterials for biosensing and biomedical applications
RM Kong, XB Zhang, Z Chen, W Tan - Small, 2011 - Wiley Online Library
Aptamers represent a class of single‐stranded DNA or RNA oligonucleotides that play
important roles in biosensing and biomedical applications. However, aptamers can gain …
important roles in biosensing and biomedical applications. However, aptamers can gain …
Bioapplications of cell-SELEX-generated aptamers in cancer diagnostics, therapeutics, theranostics and biomarker discovery: a comprehensive review
Currently, functional single-stranded oligonucleotide probes, termed aptamers, generated
by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment …
by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment …
Aptamer-functionalized nanomaterials for biological applications
Q Ren, L Ga, Z Lu, J Ai, T Wang - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Aptamers have attracted the attention of many researchers because of their high stability,
high affinity and high selectivity. Over the past decades, considerable intensive exploration …
high affinity and high selectivity. Over the past decades, considerable intensive exploration …
Recent progress in aptamer discoveries and modifications for therapeutic applications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …
The therapeutic potential of cell-internalizing aptamers
Aptamers that are evolved by the SELEX procedure (Systematic Evolution of Ligands by
Exponential enrichment) can specifically recognize and tightly bind their cognate targets by …
Exponential enrichment) can specifically recognize and tightly bind their cognate targets by …