Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Advances in single-cell technologies are transforming our understanding of cellular identity.
For instance, the application of single-cell RNA sequencing and mass cytometry …

Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex
vasculature of the kidney remains a daunting task. The molecular pathways that specify and …

Background Proximal tubular cells (PTCs) are the most abundant cell type in the kidney.
PTCs are central to normal kidney function and to regeneration versus organ fibrosis …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …

The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …

Acute kidney injury (AKI) promotes an abrupt loss of kidney function that results in
substantial morbidity and mortality. Considerable effort has gone toward identification of …

Transcriptional and proteomic profiling of individual cells have revolutionized interpretation
of biological phenomena by providing cellular landscapes of healthy and diseased tissues …

Individual cells of the same phenotype are commonly viewed as identical functional units of
a tissue or organ. However, the deep sequencing of DNA and RNA from single cells …