Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens

M Garvey - Infectious Disease Reports, 2023 - mdpi.com
The antimicrobial resistance crisis is an ongoing major threat to public health safety. Low-
and middle-income countries are particularly susceptible to higher fatality rates and the …

Progress towards the clinical use of antimicrobial peptides: challenges and opportunities

P Espinal, E Fusté, JM Sierra… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction To overcome the challenge of multidrug resistance, natural and synthetic
peptides are candidates to become the basis of innovative therapeutics, featuring diverse …

Antimicrobial peptide mimics for clinical use: does size matter?

J Svenson, N Molchanova, CI Schroeder - Frontiers in Immunology, 2022 - frontiersin.org
The search for efficient antimicrobial therapies that can alleviate suffering caused by
infections from resistant bacteria is more urgent than ever before. Infections caused by multi …

Novel peptide therapeutics for treatment of infections

PCF Oyston, MA Fox, SJ Richards… - Journal of medical …, 2009 - microbiologyresearch.org
As antibiotic resistance increases worldwide, there is an increasing pressure to develop
novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics …

Antibacterial peptides for therapeutic use: obstacles and realistic outlook

AK Marr, WJ Gooderham, REW Hancock - Current opinion in pharmacology, 2006 - Elsevier
Cationic antimicrobial peptides are produced by almost all species of life as a component of
their immediate non-specific defense against infections. The assets of these peptides in …

Antimicrobial peptides

M Malmsten - Upsala journal of medical sciences, 2014 - Taylor & Francis
With increasing antibiotics resistance, there is an urgent need for novel infection
therapeutics. Since antimicrobial peptides provide opportunities for this, identification and …

Antimicrobial peptides: an overview of a promising class of therapeutics

A Giuliani, G Pirri, S Nicoletto - Open Life Sciences, 2007 - degruyter.com
Antibiotic resistance is increasing at a rate that far exceeds the pace of new development of
drugs. Antimicrobial peptides, both synthetic and from natural sources, have raised interest …

The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

Mechanisms of antimicrobial peptide action and resistance

MR Yeaman, NY Yount - Pharmacological reviews, 2003 - ASPET
Antimicrobial peptides have been isolated and characterized from tissues and organisms
representing virtually every kingdom and phylum, ranging from prokaryotes to humans. Yet …