Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain

DM Presby, LA Checkley… - American Journal …, 2019 - journals.physiology.org
Exercise is a potent facilitator of long-term weight loss maintenance (WLM), whereby it
decreases appetite and increases energy expenditure beyond the cost of the exercise bout …

Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain

AJ Steig, MR Jackman, ED Giles… - American Journal …, 2011 - journals.physiology.org
The impact of regular exercise on energy balance, fuel utilization, and nutrient availability,
during weight regain was studied in obese rats, which had lost 17% of their weight by a …

Exercise decreases lipogenic gene expression in adipose tissue and alters adipocyte cellularity during weight regain after weight loss

ED Giles, AJ Steig, MR Jackman, JA Higgins… - Frontiers in …, 2016 - frontiersin.org
Exercise is a potent strategy to facilitate long-term weight maintenance. In addition to
increasing energy expenditure and reducing appetite, exercise also favors the oxidation of …

Short-and long-term effects of high-fat diet feeding and voluntary exercise on hepatic lipid metabolism in mice

S Yoshimura, S Nakashima, Y Tomiga… - Biochemical and …, 2018 - Elsevier
Exercise is an effective tool for improving high-fat diet induced fat accumulation in the liver.
However, the process of fat accumulation in the liver and the efficacy of early intervention …

Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner

GC Henderson, V Martinez Tenorio… - Lipids in Health and …, 2020 - Springer
Background The content of triacylglycerol (TAG) in the liver is known to rapidly increase after
a single bout of exercise followed by recovery to sedentary levels. The response of other …

Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss

PS MacLean, JA Higgins, HR Wyatt… - American Journal …, 2009 - journals.physiology.org
Weight loss is accompanied by several metabolic adaptations that work together to promote
rapid, efficient regain. We employed a rodent model of regain to examine the effects of a …

Exercise training improves liver steatosis in mice

S Alex, A Boss, A Heerschap, S Kersten - Nutrition & metabolism, 2015 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most
common liver disorder worldwide. One of the strategies that has been shown to effectively …

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

AB Jordy, MJ Kraakman, T Gardner… - American Journal …, 2015 - journals.physiology.org
The accumulation of lipid at ectopic sites, including the skeletal muscle and liver, is a
common consequence of obesity and is associated with tissue-specific and whole body …

Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model

RS Rector, GM Uptergrove, EM Morris… - American Journal …, 2011 - journals.physiology.org
The maintenance of normal body weight either through dietary modification or being
habitually more physically active is associated with reduced incidence of nonalcoholic fatty …

Exercise intensity modulation of hepatic lipid metabolism

FS Lira, LC Carnevali Jr, NE Zanchi… - Journal of nutrition …, 2012 - Wiley Online Library
Lipid metabolism in the liver is complex and involves the synthesis and secretion of very low
density lipoproteins (VLDL), ketone bodies, and high rates of fatty acid oxidation, synthesis …