Identification of a novel dual inhibitor of acetylcholinesterase and butyrylcholinesterase: in vitro and in silico studies
RBM de Almeida, DB Barbosa, MR do Bomfim… - Pharmaceuticals, 2023 - mdpi.com
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and
butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for …
butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Abstract Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are
interesting compounds for different therapeutic applications, among which Alzheimer's …
interesting compounds for different therapeutic applications, among which Alzheimer's …
Design and synthesis of new dual binding site cholinesterase inhibitors: in vitro inhibition studies with in silico docking
M Yar, M Bajda, R Atif Mehmood… - Letters in drug …, 2014 - ingentaconnect.com
Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. The
inhibition of ChEs is considered to be involved in increasing acetylcholine level in the brain …
inhibition of ChEs is considered to be involved in increasing acetylcholine level in the brain …
Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors
Background and purpose This work deals with several molecular modeling methods used to
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
Synthesis, biological evaluation, and in silico studies of new acetylcholinesterase inhibitors based on quinoxaline scaffold
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this
research, twelve quinoxaline derivatives were synthesized and evaluated as new …
research, twelve quinoxaline derivatives were synthesized and evaluated as new …
QSAR, docking, dynamic simulation and quantum mechanics studies to explore the recognition properties of cholinesterase binding sites
J Correa-Basurto, M Bello… - Chemico-biological …, 2014 - Elsevier
A set of 84 known N-aryl-monosubstituted derivatives (42 amides: series 1 and 2, and 42
imides: series 3 an 4, from maleic and succinic anhydrides, respectively) that display …
imides: series 3 an 4, from maleic and succinic anhydrides, respectively) that display …
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil
DG van Greunen, W Cordier, M Nell… - European Journal of …, 2017 - Elsevier
A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment
of Alzheimer's disease, were designed and synthesised based upon previously unexplored …
of Alzheimer's disease, were designed and synthesised based upon previously unexplored …
Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors
Novel series of coumarin-triazole and isatin-triazole hybrids were rationally designed,
synthesized and biologically evaluated to check their inhibitory potential against …
synthesized and biologically evaluated to check their inhibitory potential against …
Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors
In the present study, new tacrine derivatives containing carbamate group were synthesized
and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition …
and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition …
相关搜索
- acetylcholinesterase inhibitors biological evaluation
- acetylcholinesterase inhibitors molecular dynamics
- cholinesterase inhibitors molecular docking
- acetylcholinesterase and butyrylcholinesterase uracil derivatives
- acetylcholinesterase inhibitors quinoxaline scaffold
- acetylcholinesterase inhibitors admet prediction
- cholinesterase inhibitors molecular dynamics
- acetylcholinesterase inhibitors molecular docking