In the last decade, brain-derived neurotrophic factor (BDNF) has become increasingly
accepted as a central mediator of the effects of stress on neuronal plasticity and its …

The role of brain-derived neurotrophic factor (BDNF) in stress and affective disorders has
been studied for 10 years. Spina et al. showed in 1992 that BDNF was protective to neurons …

Several lines of evidence support the role of brain-derived neurotrophic factor (BDNF) in the
pathophysiology and pharmacotherapy of depression. 1 The neurotrophin hypothesis of …

The brain-derived neurotrophic factor (BDNF) mediates the plasticity-related changes that
associate with memory processing during sleep. Sleep deprivation and chronic stress are …

(MDD). The neurotrophic hypothesis of depression suggests that stress increases the
susceptibility to depressive illness via increased hypothalamic–pituitary–adrenal axis …

The'neurotrophin hypothesis of depression'is based largely on correlations between stress
or antidepressant treatment and down-or upregulation, respectively, of brain-derived …

The protein brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family
of growth factors involved in plasticity of neurons in several brain regions. There are …

BDNF by intracellular and extracellular proteases (Fig. 1). Interestingly, BDNF (mature form)
and BDNF propeptide (~ 17 kDa) are~ tenfold more abundant than proBDNF in the adult …

The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that a
loss of BDNF function is directly involved in the pathophysiology of depression and its …

One of the leading neurobiological hypotheses on depression states that decreased
expression of brain-derived neurotrophic factor (BDNF) contributes to depression. This is …