Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although
the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with …

Skp2 is an F-box protein that forms the SCF complex with Skp1 and Cullin-1 to constitute an
E3 ligase for ubiquitylation. Ubiquitylation and degradation of the p27 are critical for Skp2 …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the
key players regulating cell cycle progression is the F‐box protein Skp2. Skp2 forms a SCF …

Deregulated Skp2 function promotes cell transformation, and this is consistent with
observations of Skp2 overexpression in many human cancers. However, the mechanisms …

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-
cycle progression, senescence, metabolism, cancer progression, and metastasis. In the …

Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin–
protein ligase complexes that has been implicated in the ubiquitin-mediated degradation of …

The F box protein Skp2 is oncogenic, and its frequent amplification and overexpression
correlate with the grade of malignancy of certain tumors. Conversely, depletion of Skp2 …

In colorectal tumors, S-phase kinase-associated protein 2 (Skp2) still has numerous
important questions unanswered: its expression in adenomas, its correlation with key …

SKP2, an F-box protein constituting the substrate recognition subunit of the SCFSKP2
ubiquitin ligase complex, is implicated in ubiquitin-mediated degradation of the cyclin …