Background: Tacrolimus (TAC) and mycophenolic acid (MPA) are the main
immunosuppressive drugs used in pediatric kidney transplantation. Single nucleotide …

Ferraris JR, Argibay PF, Costa L, Jimenez G, Coccia PA, Ghezzi LFR, Ferraris V, Belloso
WH, Redal MA, Larriba JM. Influence of CYP3A5 polymorphism on tacrolimus maintenance …

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a
narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms …

Immunosuppressant drugs (ISDs) are routinely used in clinical practice to maintain organ
transplant survival. However, these drugs are characterized by a restricted therapeutic …

Background: The pharmacokinetics of tacrolimus (TAC) and mycophenolic acid (MPA) are
highly variable. An impact of single-nucleotide polymorphisms (SNPs) of the genes coding …

Aim: Meta-analyses and large cohort studies provide confusing results on the association of
the CYP3A5 6986A> G allelic variant and adverse outcomes in kidney transplant recipients …

Transplant recipients receive potent immunosuppressive drugs in order to prevent graft
rejection. Therapeutic drug monitoring is the current approach to guide the dosing of …

BACKGROUND: The pharmacokinetics of tacrolimus (TRL) are clearly affected by genetic
polymorphisms in drug-metabolizing enzymes, which lead to large interindividual …

Background Optimal management of immunosuppression in kidney transplantation requires
a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are …

Objective Cyclosporine A (CsA) is a substrate of cytochrome P450 3A4 (CYP3A4). Recently,
a newly discovered intron 6 single-nucleotide polymorphism in CYP3A4 (rs35599367 C> T) …