(R= EtO or i-BuNH) and with the C-terminal amino acid proline either blocked (R'= OBzl) or
free (R'= OH). These compounds were vised to investigate the recently reported selectivity of …

The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are
reported. Exploration of the properties of the S1 subsite with a series of α-amino aldehyde …

Prior reports from our laboratories have identified the nonpeptidic inhibitor 2 as a potent and
selective Cathepsin K (Cat K) inhibitor. Modelling studies suggested that the introduction of …

Nonpeptidic, selective, and potent cathepsin S inhibitors were derived from an in-house
pyrrolopyrimidine cathepsin K inhibitor by modification of the P2 and P3 moieties. The …

Cathepsins are proteases found in all animals as well as other organisms. There are
approximately a dozen members of this family, which are distinguished by their structure …

In this study we report on the synthesis, kinetic characterization and application of a novel
biotinylated and active-site-directed inactivator of cathepsin B. Thus the …

The crystal structure of the inhibitor NS-134 in complex with bovine cathepsin B reveals that
functional groups attached to both sides of the epoxysuccinyl reactive group bind to the part …

Introduction: Cathepsins play an important role in protein degradation and processing.
Aberrant cathepsin B or L is closely associated with many serious diseases such as cancer …

The 13.5 kDa N-terminal part of the propeptide remains associated with mature cathepsin C
after proteolytic activation and excision of the activation peptide. This residual pro-part …