The mysteries of capsaicin-sensitive afferents
A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …
Mechanisms and clinical uses of capsaicin
SK Sharma, AS Vij, M Sharma - European journal of pharmacology, 2013 - Elsevier
Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …
Molecular mechanisms of nociception
M Tominaga, M Numazaki, T Iida… - Nihon Shinkei Seishin …, 2003 - europepmc.org
Capsaicin, the main ingredient in'hot'chili peppers, elicits burning pain by activating
nociceptors. The cloned capsaicin receptor (TRPV1) is a nonselective cation channel with …
nociceptors. The cloned capsaicin receptor (TRPV1) is a nonselective cation channel with …
Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1
L Vyklický, A Lyfenko, K Sušánková, J Teisinger… - Neuroscience, 2002 - Elsevier
The vanilloid receptor subtype 1 (VR1) is expressed in a sub-population of small dorsal root
ganglion (DRG) neurones in mammals and serves as the common transducer of the pain …
ganglion (DRG) neurones in mammals and serves as the common transducer of the pain …
Capsaicin receptor in the pain pathway
M Tominaga, D Julius - The Japanese Journal of Pharmacology, 2000 - jstage.jst.go.jp
抄録 Capsaicin, the main pungent ingredient in 'hot'chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned capsaicin …
activating specific (vanilloid) receptors on sensory nerve endings. The cloned capsaicin …
[引用][C] NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS-Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N …
MA Schumacher, I Moff, SP Sudanagunta… - Journal of Biological …, 2000 - Baltimore [etc.]
[HTML][HTML] Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1
PM Blumberg - Molecular Interventions, 2007 - triggered.edina.clockss.org
The natural product capsaicin, the pungent constituent in hot peppers, has long provided a
window into hyperalgesia, neurogenic inflammation, and thermoregulation (1, 2). Capsaicin …
window into hyperalgesia, neurogenic inflammation, and thermoregulation (1, 2). Capsaicin …
Acid potentiation of the capsaicin receptor determined by a key extracellular site
SE Jordt, M Tominaga, D Julius - Proceedings of the …, 2000 - National Acad Sciences
The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …
TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate
T Iida, T Moriyama, K Kobata, A Morita, N Murayama… - …, 2003 - Elsevier
Capsiate is a capsaicin-like ingredient of a non-pungent cultivar of red pepper, CH-19
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …
Structural determinant of TRPV1 desensitization interacts with calmodulin
M Numazaki, T Tominaga, K Takeuchi… - Proceedings of the …, 2003 - National Acad Sciences
The capsaicin receptor, TRPV1 (VR1), is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. Extracellular Ca2+ …
as a polymodal detector of pain-producing chemical and physical stimuli. Extracellular Ca2+ …