Needs and opportunities in bio-design automation: four areas for focus

E Appleton, D Densmore, C Madsen… - Current Opinion in …, 2017 - Elsevier
Bio-design automation (BDA) is an emerging field focused on computer-aided design,
engineering principles, and automated manufacturing of biological systems. Here we …

Bio-design automation: software+ biology+ robots

DM Densmore, S Bhatia - Trends in biotechnology, 2014 - cell.com
Synthetic biology promises to usher in a new era of scientific innovation and discovery [1].
Applicationsof thistechnology are broad and diverse [2]. Although applications frequently …

[HTML][HTML] Bridging the gap: a roadmap to breaking the biological design barrier

J Beal - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This paper presents an analysis of an emerging bottleneck in organism engineering, and
paths by which it may be overcome. Recent years have seen the development of a profusion …

[HTML][HTML] DeviceEditor visual biological CAD canvas

J Chen, D Densmore, TS Ham, JD Keasling… - Journal of biological …, 2012 - Springer
Abstract Background Biological Computer Aided Design (bioCAD) assists the de novo
design and selection of existing genetic components to achieve a desired biological activity …

Integration of microfluidics into the synthetic biology design flow

H Huang, D Densmore - Lab on a Chip, 2014 - pubs.rsc.org
One goal of synthetic biology is to design and build genetic circuits in living cells for a range
of applications. Major challenges in these efforts include increasing the scalability and …

[引用][C] Synthesis aided design: The biological design‐build‐test engineering paradigm?

RT Gill, AL Halweg‐Edwards… - Biotechnology and …, 2016 - Wiley Online Library
An open question in biotechnology concerns the extent to which rapid advancements in
DNA reading and writing technologies will shift current paradigms in the engineering of …

Fluigi: An end-to-end software workflow for microfluidic design

H Huang - 2016 - search.proquest.com
One goal of synthetic biology is to design and build genetic circuits in living cells for a range
of applications with implications in health, materials, and sensing. Computational design …

Design automation in synthetic biology

E Appleton, C Madsen, N Roehner… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Design automation refers to a category of software tools for designing systems that work
together in a workflow for designing, building, testing, and analyzing systems with a target …

[图书][B] Design automation methods and tools for microfluidics-based biochips

K Chakrabarty, J Zeng - 2006 - Springer
Microfluidics-based biochips, also called lab-on-a-chip, are becoming increasingly popular
as a technology platform for the detection, analysis and manipulation of biochemical …

Synthetic biology: an emerging engineering discipline

AA Cheng, TK Lu - Annual review of biomedical engineering, 2012 - annualreviews.org
Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …