Cathelicidin host defense peptides and inflammatory signaling: Striking a balance
Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates.
While their antibacterial activity toward bacterial cells was the original focus for research …
While their antibacterial activity toward bacterial cells was the original focus for research …
Host-defense peptides: from biology to therapeutic strategies
ML Mangoni - Cellular and Molecular Life Sciences, 2011 - Springer
Primitive innate defense mechanisms in the form of gene-encoded antimicrobial peptides
are now considered as potential candidates for the development of new therapeutics. They …
are now considered as potential candidates for the development of new therapeutics. They …
Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential
Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role
in the response to infection and inflammation in all complex life forms. It is increasingly …
in the response to infection and inflammation in all complex life forms. It is increasingly …
Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections
A Nijnik, REW Hancock - Emerging health threats journal, 2009 - Taylor & Francis
The rapidly increasing incidence of multidrug-resistant infections and the alarmingly low rate
of discovery of conventional antibiotics create an urgent need for alternative strategies to …
of discovery of conventional antibiotics create an urgent need for alternative strategies to …
Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?
L Steinstraesser, UM Kraneburg, T Hirsch… - International journal of …, 2009 - mdpi.com
Host defense peptides can modulate the innate immune response and boost infection-
resolving immunity, while dampening potentially harmful pro-inflammatory (septic) …
resolving immunity, while dampening potentially harmful pro-inflammatory (septic) …
[HTML][HTML] Utilizing organoid and air-liquid interface models as a screening method in the development of new host defense peptides
Host defence peptides (HDPs), also known as antimicrobial peptides, are naturally occurring
polypeptides (~ 12-50 residues) composed of cationic and hydrophobic amino acids that …
polypeptides (~ 12-50 residues) composed of cationic and hydrophobic amino acids that …
A re-evaluation of the role of host defence peptides in mammalian immunity
DME Bowdish, DJ Davidson… - Current Protein and …, 2005 - ingentaconnect.com
Host defence peptides are found in all classes of life and are a fundamental component of
the innate immune response. Initially it was believed that their sole role in innate immunity …
the innate immune response. Initially it was believed that their sole role in innate immunity …
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
AL Hilchie, K Wuerth, REW Hancock - Nature chemical biology, 2013 - nature.com
Cationic host defense (antimicrobial) peptides were originally studied for their direct
antimicrobial activities. They have since been found to exhibit multifaceted …
antimicrobial activities. They have since been found to exhibit multifaceted …
Host defense peptides: Dual antimicrobial and immunomodulatory action
M Drayton, JP Deisinger, KC Ludwig… - International Journal of …, 2021 - mdpi.com
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial
infections to become a global health concern. Antimicrobial peptides (AMPs), also known as …
infections to become a global health concern. Antimicrobial peptides (AMPs), also known as …
Cationic host defense (antimicrobial) peptides
KL Brown, REW Hancock - Current opinion in immunology, 2006 - Elsevier
Members of the cationic host defense (antimicrobial) peptide family are widely distributed in
nature, existing in organisms from insects to plants to mammals and non-mammalian …
nature, existing in organisms from insects to plants to mammals and non-mammalian …