Host Defence (bdCationic) Peptides: What Is Their Future Clinical Potential?

REW Hancock - Drugs, 1999 - Springer
Host defence, cationic antimicrobial peptides are now recognised as an important
component, in most species, of the early innate and induced defences against invading …

Multifunctional antimicrobial peptides: therapeutic targets in several human diseases

M Zaiou - Journal of Molecular Medicine, 2007 - Springer
Antimicrobial peptides have emerged as promising agents against antibiotic-resistant
pathogens. They represent essential components of the innate immunity and permit humans …

[HTML][HTML] Dietary nutrients mediate intestinal host defense peptide expression

J Wu, N Ma, LJ Johnston, X Ma - Advances in nutrition, 2020 - Elsevier
The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient
digestion and absorption, and microbial survival. The gut in animals faces continuous …

Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Host antimicrobial defence peptides in human disease

B Agerberth, GH Guðmundsson - Antimicrobial peptides and human …, 2006 - Springer
Antimicrobial peptides or host defence peptides are endogenous peptide antibiotics, which
have been confirmed as an essential part of the immune system. Apart from direct killing of …

Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli

B Bommarius, H Jenssen, M Elliott, J Kindrachuk… - Peptides, 2010 - Elsevier
Cationic antimicrobial host defense peptides (HDPs) combat infection by directly killing a
wide variety of microbes, and/or modulating host immunity. HDPs have great therapeutic …

Potential of immunomodulatory host defense peptides as novel anti-infectives

DM Easton, A Nijnik, ML Mayer, REW Hancock - Trends in biotechnology, 2009 - cell.com
A fundamentally new strategy for the treatment of infectious disease is the modulation of host
immune responses to enhance clearance of infectious agents and reduce tissue damage …

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

MW Robinson, S Donnelly, AT Hutchinson, J To… - PLoS …, 2011 - journals.plos.org
Over the last decade a significant number of studies have highlighted the central role of host
antimicrobial (or defence) peptides in modulating the response of innate immune cells to …

The secrets of dermcidin action

M Burian, B Schittek - International journal of medical microbiology, 2015 - Elsevier
Antimicrobial peptides (AMPs) are important effector molecules of the innate immune
defense of diverse species. The majority of known AMPs are cationic therefore facilitating …

Cationic antimicrobial peptides and their multifunctional role in the immune system

MG Scott, REW Hancock - Critical Reviews™ in Immunology, 2000 - dl.begellhouse.com
Many species of life contain cationic antimicrobial peptides as components of their immune
systems. The antimicrobial activity of these peptides has been studied extensively, and …