Shock is defined as a state in which the circulation is unable to deliver sufficient oxygen to
meet the demands of the tissues, resulting in cellular dysoxia and organ failure. In this …

Shock, defined at a cellular level, is a condition in which oxygen delivery to the cells is not
sufficient to sustain cellular activity and support organ function. The central role of …

Macrohemodynamic targets such as mean arterial pressure, cardiac output, and mixed or
central venous oxygen saturation have been used to guide treatment of patients presenting …

Microvascular alterations are a hallmark of sepsis and play a crucial role in its
pathophysiology. Such alterations are the result of overwhelming inflammation, which …

Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that
maintaining systemic blood pressure is associated with inadequate perfusion of the …

Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental
advances have increased our understanding of the role of the microcirculation in shock …

New insights into the pathophysiology of cardiogenic shock:... : Current Opinion in Critical
Care New insights into the pathophysiology of cardiogenic shock: the role of the …

This review examines experimental evidence that the microvascular dysfunction that occurs
early in sepsis is the critical first stage in tissue hypoxia and organ failure. A functional …

The microcirculation is a complex system, which regulates the balance between oxygen
demand and supply of parenchymal cells. In addition, the peripheral microcirculation has an …

Microcirculatory alterations, frequently observed in shock states, are associated with the
development of multiple organ failure and death. These microcirculatory alterations occur …