Genomic sequencing in clinical trials
Human genome sequencing is the process by which the exact order of nucleic acid base
pairs in the 24 human chromosomes is determined. Since the completion of the Human …
pairs in the 24 human chromosomes is determined. Since the completion of the Human …
Emerging DNA sequencing technologies for human genomic medicine
RL Strausberg, S Levy, YH Rogers - Drug discovery today, 2008 - Elsevier
The completion of draft sequences of the human genome represented a remarkable
achievement for automated DNA sequencing based on Sanger technology. However, the …
achievement for automated DNA sequencing based on Sanger technology. However, the …
Four generations of sequencing: Is it ready for the clinic yet?
S Srinivasan, J Batra - Journal of Next Generation Sequencing & …, 2014 - eprints.qut.edu.au
Next-generation sequencing techniques have revolutionized over the last decade providing
researchers with low cost, high-throughput alternatives compared to the traditional Sanger …
researchers with low cost, high-throughput alternatives compared to the traditional Sanger …
High-throughput sequencing technologies
JA Reuter, DV Spacek, MP Snyder - Molecular cell, 2015 - cell.com
The human genome sequence has profoundly altered our understanding of biology, human
diversity, and disease. The path from the first draft sequence to our nascent era of personal …
diversity, and disease. The path from the first draft sequence to our nascent era of personal …
[HTML][HTML] Opportunities and challenges for the integration of massively parallel genomic sequencing into clinical practice: lessons from the ClinSeq project
LG Biesecker - Genetics in Medicine, 2012 - Elsevier
Purpose The debate surrounding the return of results from high-throughput genomic
interrogation encompasses many important issues including ethics, law, economics, and …
interrogation encompasses many important issues including ethics, law, economics, and …
[引用][C] The end of the beginning: the race to begin human genome sequencing
M Boguski, A Chakravarti, R Gibbs, E Green… - Genome …, 1996 - genome.cshlp.org
The Human Genome Project has different meanings to different scientists, but the essence of
it has always been the drive to obtain the total reference genome sequence for humans. In …
it has always been the drive to obtain the total reference genome sequence for humans. In …
Clinical genome sequencing
The completion of the first draft of the Human Genome Project in 2001, and subsequent
refinements since then, have stimulated an explosion of research about the human genome …
refinements since then, have stimulated an explosion of research about the human genome …
Controversy and debate on clinical genomics sequencing—paper 1: genomics is not exceptional: rigorous evaluations are necessary for clinical applications of …
BJ Wilson, FA Miller, F Rousseau - Journal of Clinical Epidemiology, 2017 - Elsevier
Next generation genomic sequencing (NGS) technologies—whole genome and whole
exome sequencing—are now cheap enough to be within the grasp of many health care …
exome sequencing—are now cheap enough to be within the grasp of many health care …
[HTML][HTML] Next generation sequencing: from research area to clinical practice
C Di Resta, M Ferrari - Ejifcc, 2018 - ncbi.nlm.nih.gov
Translating the power of high-throughput sequencing technologies from research area into
clinical medicine is one of the major goal for several researchers and health-care providers …
clinical medicine is one of the major goal for several researchers and health-care providers …
Next generation DNA sequencing and the future of genomic medicine
MW Anderson, I Schrijver - Genes, 2010 - mdpi.com
In the years since the first complete human genome sequence was reported, there has been
a rapid development of technologies to facilitate high-throughput sequence analysis of DNA …
a rapid development of technologies to facilitate high-throughput sequence analysis of DNA …