Background Melanoma is among the most aggressive forms of cancer. Our latest
retrospective analysis showed that recombinant human interferon-alpha1b (IFN-α1b) led to …

Simple Summary The crucial immune stimulatory functions exerted by Type I Interferons
(IFNs) in cancer settings have been not only widely demonstrated during the last fifty years …

The discovery that type I interferon (IFN-α/β) inhibited tumor cell growth was welcomed
initially with great excitement as it rapidly became a US Food and Drug Administration …

Interferons‐alpha (IFN‐α) are a group of cytokines belonging to type I IFN family, which exert
multiple biological effects, including antiviral and antitumor activities in patients with defined …

Type I interferons (IFNs) exert anti-proliferative, antiviral and immunomodulatory activities.
They are also involved in cell differentiation and anti-tumor defense processes. A growing …

Type I IFN (IFN-α/β) have important biological functions ranging from immune cell
development and activation, to tumor cell killing and most importantly inhibition of virus …

The apoptotic effects of interferon lambdas (IFNλs) have been described in several types of
cancers. However, their effects on human lung cancer cells and the mechanisms are …

Type I interferons (IFNs) represent a group of cytokines that act through a common receptor
composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies …

Type I interferon (IFN) was originally identified as an immunomodulatory cytokine because
of its antiviral activity. Further characterization of its biological effects revealed a prominent …

Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important
effector molecule of anti-tumor immunity, capable of suppressing tumor growth through …