Antileishmanial activity of pyrazolopyridine derivatives and their potential as an adjunct therapy with miltefosine
A series of pyrazolo (dihydro) pyridines was synthesized and evaluated for antileishmanial
efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d and 6j …
efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d and 6j …
Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents
In pursuance of our efforts to expand the scope of novel antileishmanial entities, a series of
thirty-five quinoline-piperazine/pyrrolidine, and other heterocyclic amine derivatives were …
thirty-five quinoline-piperazine/pyrrolidine, and other heterocyclic amine derivatives were …
Effect of 1, 2, 3-triazole salts, non-classical bioisosteres of miltefosine, on Leishmania amazonensis
PHF Stroppa, LMR Antinarelli, AML Carmo… - Bioorganic & Medicinal …, 2017 - Elsevier
Here, we report the effect of new non-classical bioisosteres of miltefosine on Leishmania
amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing …
amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing …
Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents
SN Suryawanshi, S Kumar, R Shivahare… - Bioorganic & medicinal …, 2013 - Elsevier
A series of substituted aryl pyrimidine derivatives was synthesized and evaluated in vitro for
their antileishmanial potential against intracellular amastigotes of Leishmania donovani …
their antileishmanial potential against intracellular amastigotes of Leishmania donovani …
1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in Leishmania amazonensis Promastigote: An in Vitro Antileishmanial and in Silico …
F Almeida-Souza, VD Silva, GX Silva… - International Journal of …, 2020 - mdpi.com
The current standard treatment for leishmaniasis has remained the same for over 100 years,
despite inducing several adverse effects and increasing cases of resistance. In this study we …
despite inducing several adverse effects and increasing cases of resistance. In this study we …
New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies
In a search for new drug candidates for one of the neglected tropical diseases,
leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro …
leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro …
4-Amino bis-pyridinium derivatives as novel antileishmanial agents
V Gómez-Pérez, JI Manzano… - Antimicrobial agents …, 2014 - Am Soc Microbiol
The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of
pentamidine have been investigated, and all compounds assayed were found to display …
pentamidine have been investigated, and all compounds assayed were found to display …
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives
IF Prinsloo, NH Zuma, J Aucamp… - Chemical Biology & …, 2021 - Wiley Online Library
Currently available drugs being used to treat leishmaniasis have several shortcomings,
including high toxicity, drug administration that requires hospitalization, and the emergence …
including high toxicity, drug administration that requires hospitalization, and the emergence …
Synthesis and biological evaluation of 2, 3-diarylimidazo [1, 2-a] pyridines as antileishmanial agents
S Marhadour, P Marchand, F Pagniez, MA Bazin… - European journal of …, 2012 - Elsevier
A novel series of 2, 3-diarylimidazo [1, 2-a] pyridines was synthesized and evaluated for
their antileishmanial activities. Four derivatives exhibited good activity against the …
their antileishmanial activities. Four derivatives exhibited good activity against the …
Miltefosine: oral treatment of leishmaniasis
The well-known problems of classic treatment of the leishmaniases with pentavalent
antimony (reduced efficacy), difficulties of administration and increasing frequency and …
antimony (reduced efficacy), difficulties of administration and increasing frequency and …