Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

In sickness and in health: perineuronal nets and synaptic plasticity in psychiatric disorders

H Pantazopoulos, S Berretta - Neural plasticity, 2016 - Wiley Online Library
Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

The extracellular matrix and perineuronal nets in memory

JW Fawcett, M Fyhn, P Jendelova, JCF Kwok… - Molecular …, 2022 - nature.com
All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

[HTML][HTML] The “loss” of perineuronal nets in Alzheimer's disease: missing or hiding in plain sight?

JM Scarlett, SJ Hu, KM Alonge - Frontiers in Integrative Neuroscience, 2022 - frontiersin.org
Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing
extracellular matrix structures that assemble around neurons involved in learning, memory …

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

S Yang, S Gigout, A Molinaro, Y Naito-Matsui… - Molecular …, 2021 - nature.com
Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on
the neuronal surface that have been implicated in the control of neuroplasticity and memory …

Chondroitin 6‐sulfation regulates perineuronal net formation by controlling the stability of aggrecan

S Miyata, H Kitagawa - Neural plasticity, 2016 - Wiley Online Library
Perineuronal nets (PNNs) are lattice‐like extracellular matrix structures composed of
chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline …