Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …

Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …

Chromosomal rearrangements are a frequent cause of oncogene deregulation in human
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …

EVI1, located at chromosome band 3q26, encodes a 1051 amino acid zinc finger protein
inappropriately expressed in the leukemic cells of 2–5% of acute myeloid leukemia (AML) …

The development of acute myelogenous leukemia (AML), which is characterized by a block
of myeloid differentiation, is a multi-step process that involves several genetic abnormalities …

The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band
3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 …

Abstract The AML1/EVI-1 chimeric gene is generated by the t (3; 21)(q26; q22) translocation
and plays a pivotal role in progression of hematopoietic stem cell malignancies such as …

Abstract The t (3; 21)(q26; q22) chromosomal translocation associated with blastic crisis of
chronic myelogenous leukemia results in the formation of the AML1/Evi-1 chimeric protein …

Acute myeloid leukemia (AML) with inv (3)/t (3; 3)(q21q26) is a distinct World Health
Organization recognized entity, characterized by its aggressive course and poor prognosis …

Abstract The t (12; 21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion
gene, is the most common chromosomal rearrangement in childhood cancer and is …