Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene–driven myeloid leukemia
CK Lopez, E Noguera, V Stavropoulou, E Robert, Z Aid… - Cancer discovery, 2019 - AACR
Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the
specific associations between age and phenotype. We observed that fusion oncogenes …
specific associations between age and phenotype. We observed that fusion oncogenes …
MLL-AF4 spreading identifies binding sites that are distinct from super-enhancers and that govern sensitivity to DOT1L inhibition in leukemia
J Kerry, L Godfrey, E Repapi, M Tapia, NP Blackledge… - Cell Reports, 2017 - cell.com
Understanding the underlying molecular mechanisms of defined cancers is crucial for
effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene …
effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene …
Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
F Fazi, S Racanicchi, G Zardo, LM Starnes, M Mancini… - Cancer cell, 2007 - cell.com
Hematopoietic transcription factors are involved in chromosomal translocations, which
generate fusion proteins contributing to leukemia pathogenesis. Analysis of patient's primary …
generate fusion proteins contributing to leukemia pathogenesis. Analysis of patient's primary …
Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP
Chromosomal translocations are a genomic hallmark of many hematologic malignancies.
Often as initiating events, these structural abnormalities result in fusion proteins involving …
Often as initiating events, these structural abnormalities result in fusion proteins involving …
The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures
A Benedikt, S Baltruschat, B Scholz, A Bursen… - Leukemia, 2011 - nature.com
Expression of the AF4–MLL fusion protein in murine hematopoietic progenitor/stem cells
results in the development of proB acute lymphoblastic leukemia. In this study, we affinity …
results in the development of proB acute lymphoblastic leukemia. In this study, we affinity …
EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
VP Lavallée, P Gendron, S Lemieux… - Blood, The Journal …, 2015 - ashpublications.org
The genetic and transcriptional signature of EVI1 (ecotropic viral integration site 1)-
rearranged (EVI1-r) acute myeloid leukemias (AMLs) remains poorly defined. We performed …
rearranged (EVI1-r) acute myeloid leukemias (AMLs) remains poorly defined. We performed …