Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip±cleft palate and cleft palate only
KU Ludwig, AC Böhmer, J Bowes… - Human molecular …, 2017 - academic.oup.com
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common
human birth defects with multifactorial etiology. Here, we present results from a genome …
human birth defects with multifactorial etiology. Here, we present results from a genome …
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
LJ Howe, MK Lee, GC Sharp, G Davey Smith… - PLoS …, 2018 - journals.plos.org
There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate
(nsCL/P) are also associated with normal-range variation in facial morphology. However …
(nsCL/P) are also associated with normal-range variation in facial morphology. However …
Non-syndromic cleft lip with or without cleft palate: genome-wide association study in europeans identifies a suggestive risk locus at 16p12. 1 and supports …
IALM van Rooij, KU Ludwig, J Welzenbach, N Ishorst… - Genes, 2019 - mdpi.com
Non-syndromic cleft lip with or without cleft palate (nsCL/P) ranks among the most common
human congenital malformations, and has a multifactorial background in which both …
human congenital malformations, and has a multifactorial background in which both …
Six NSCL/P loci show associations with normal-range craniofacial variation
K Indencleef, J Roosenboom, H Hoskens… - Frontiers in …, 2018 - frontiersin.org
Objectives: Orofacial clefting is one of the most prevalent craniofacial malformations.
Previous research has demonstrated that unaffected relatives of patients with non-syndromic …
Previous research has demonstrated that unaffected relatives of patients with non-syndromic …
[HTML][HTML] Genetic factors influencing risk to orofacial clefts: today's challenges and tomorrow's opportunities
TH Beaty, ML Marazita, EJ Leslie - F1000Research, 2016 - ncbi.nlm.nih.gov
Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …
combined represent the largest group of craniofacial malformations in humans with an …
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24. 2, 17q23 and 19q13
Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …
Candidate genes for nonsyndromic cleft palate detected by exome sequencing
AK Hoebel, D Drichel, M Van De Vorst… - Journal of dental …, 2017 - journals.sagepub.com
Nonsyndromic cleft palate only (nsCPO) is a facial malformation that has a livebirth
prevalence of 1 in 2,500. Research suggests that the etiology of nsCPO is multifactorial, with …
prevalence of 1 in 2,500. Research suggests that the etiology of nsCPO is multifactorial, with …
Identifying genetic sources of phenotypic heterogeneity in orofacial clefts by targeted sequencing
JC Carlson, MA Taub, E Feingold, TH Beaty… - Birth defects …, 2017 - Wiley Online Library
Background Orofacial clefts (OFCs), including nonsyndromic cleft lip with or without cleft
palate (NSCL/P), are common birth defects. NSCL/P is highly heterogeneous with multiple …
palate (NSCL/P), are common birth defects. NSCL/P is highly heterogeneous with multiple …
Nonsyndromic cleft lip with or without cleft palate in arab populations: Genetic analysis of 15 risk loci in a novel case–control sample recruited in Yemen
KA Aldhorae, AC Böhmer, KU Ludwig… - … Research Part A …, 2014 - Wiley Online Library
Background Nonsyndromic orofacial clefting (nsOFC) is among the most common of all
congenital disorders and has a genetically complex etiology. Based on embryological and …
congenital disorders and has a genetically complex etiology. Based on embryological and …
Evidence for SNP‐SNP interaction identified through targeted sequencing of cleft case‐parent trios
Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial
birth defect in humans, affecting 1 in 700 live births. This malformation has a complex …
birth defect in humans, affecting 1 in 700 live births. This malformation has a complex …
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