Long non-coding RNA GAS5 promotes BAX expression by competing with microRNA-128-3p in response to 5-fluorouracil

H Lee, H Kang, C Kim, JL Ku, S Nam, EK Lee - Biomedicines, 2022 - mdpi.com
The acquisition of drug resistance is a major hurdle for effective cancer treatment. Although
several efforts have been made to overcome drug resistance, the underlying mechanisms …

Research progress of long non-coding RNA GAS5 in malignant tumors

G Lin, T Wu, X Gao, Z He, W Nong - Frontiers in Oncology, 2022 - frontiersin.org
With completing the whole genome sequencing project, awareness of lncRNA further
deepened. The growth arrest-specific transcript 5 (GAS5) was initially identified in growth …

[HTML][HTML] Long non-coding RNA GAS5 antagonizes the chemoresistance of pancreatic cancer cells through down-regulation of miR-181c-5p

ZQ Gao, J Wang, DH Chen, XS Ma, W Yang… - Biomedicine & …, 2018 - Elsevier
Objective To explore the core mechanism of long non-coding RNA (lncRNA) growth arrest-
specific transcript 5 (GAS5) in the regulation of multidrug resistance of pancreatic cancer …

A critical role for the long non‐coding RNA GAS5 in proliferation and apoptosis in non‐small‐cell lung cancer

X Shi, M Sun, H Liu, Y Yao, R Kong… - Molecular …, 2015 - Wiley Online Library
In more recent years, long non‐coding RNAs (lncRNAs) have been investigated as a new
class of regulators of cellular processes, such as cell growth, apoptosis, and carcinogenesis …

[HTML][HTML] Long noncoding RNA GAS5 suppresses tumorigenesis by inhibiting miR-23a expression in non-small cell lung cancer

Y Mei, J Si, Y Wang, Z Huang, H Zhu, S Feng… - Oncology …, 2017 - ncbi.nlm.nih.gov
Previous studies reported that elevated expression of long noncoding RNA (lncRNA) GAS5
led to the arrest of non-small cell lung cancer (NSCLC) cell growth and a promotion of …

Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by …

L Chang, C Li, T Lan, L Wu… - Molecular …, 2016 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑related mortality
worldwide. Recent studies have demonstrated that long non‑coding RNAs (lncRNAs) are …

Long non‑coding RNA GAS5 inhibits cell proliferation, induces G0/G1 arrest and apoptosis, and functions as a prognostic marker in colorectal cancer

Y Yang, Z Shen, Y Yan, B Wang… - Oncology …, 2017 - spandidos-publications.com
Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment
remains a challenge. Effective control of cell survival and proliferation is critical in the …

Overexpression of growth-arrest-specific transcript 5 improved cisplatin sensitivity in hepatocellular carcinoma through sponging miR-222

P Zhao, X Cui, L Zhao, L Liu, D Wang - DNA and Cell Biology, 2020 - liebertpub.com
Long noncoding RNA growth-arrest-specific transcript 5 (GAS5) has been proved to play a
crucial role in cancer chemoresistance. However, the function of GAS5 and its underlying …

Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222

X Zhao, P Wang, J Liu, J Zheng, Y Liu, J Chen, Y Xue - Molecular Therapy, 2015 - cell.com
Aberrant expression of noncoding RNAs in glioma cells, including long noncoding RNAs
(lncRNAs) and microRNAs, may participate in the progression of glioma. Encoded by …

Long non‐coding RNA GAS 5 is induced by interferons and plays an antitumor role in esophageal squamous cell carcinoma

J Huang, Y Li, Z Lu, Y Che, S Sun, S Mao… - Cancer …, 2018 - Wiley Online Library
The long non‐coding RNA GAS 5 has been reported as a tumor suppressor in many
cancers. However, its functions and mechanisms remain largely unknown in esophageal …