Skin is the largest organ of human body, acting as a barrier with protective, immunologic and
sensorial functions. Its permanent exposure to the external environment can result in …

The global volume of skin damage or injuries has major healthcare implications and,
accounts for about half of the world's annual expenditure in the healthcare sector. In the last …

Chronic wounds occur as a consequence of a prolonged inflammatory phase during the
healing process, which precludes skin regeneration. Typical treatment for chronic wounds …

The skin is responsible for several important physiological functions and has enormous
clinical significance in wound healing. Tissue engineered substitutes may be used in …

Skin tissue engineering has attained several clinical milestones making remarkable
progress over the past decades. Skin is inhabited by a plethora of cells spatiotemporally …

Tissue-engineered skin is a significant advance in the field of wound healing. It has mainly
been developed because of limitations associated with the use of autografts and allografts …

The formation of severe scars still represents the result of the closure process of extended
and deep skin wounds. To address this issue, different bioengineered skin substitutes have …

The skin is the largest human organ system. Loss of skin integrity due to injury or illness
results in a substantial physiologic imbalance and ultimately in severe disability or death …

Regenerative medicine and tissue engineering (TE) have experienced significant advances
in the development of in vitro engineered skin substitutes, either for replacement of lost …

Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical
scarring contribute to the incomplete or partial loss of function and aesthetic concerns in skin …