Type 2 nitric oxide synthase (NOS2) is required for the Th1-dependent healing of infections
with intracellular microbes, including Leishmania major. Here, we demonstrate the …

The production of nitric oxide (NO) by the inducible NO synthase (iNOS) is a key defense
mechanism against intracellular pathogens such as Leishmania. Numerous studies have …

TNF participates in the induction of nitric oxide (NO) production and macrophage activation,
leading to the elimination of intracellular pathogens. We previously found that TNF receptor …

Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …

Nitric oxide (NO) production is critical for the host defense against intracellular pathogens;
however, it is unclear whether NO-dependent control of intracellular organisms depends on …

Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a
disease that affects more than 12 million people worldwide. These parasites replicate …

Cutaneous leishmaniasis affects millions of people around the world. Several species of
Leishmania infect mouse strains, and murine models closely reproduce the cutaneous …

In the Leishmania major mouse model of cutaneous leishmaniasis inducible nitric oxide
synthase (iNOS) is crucial for the killing of the parasite in the skin and draining lymph node …

Abstract Type I IFNs (IFN-α/β) have only recently gained considerable attention as
immunomodulators in nonviral infectious diseases. IFN-β has been shown to protect, in a …

ABSTRACT Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for
the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast …