Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …

Proteoglycans are abundant components of the cell surface and extracellular matrix that
mediate critical interactions between cells and their environment. They play a variety of …

Large numbers of proteins in animal tissues occur immobilized in the extracellular space, at
cell surfaces or in the extracellular matrix. Some are anchored through interactions with …

Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-
bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and …

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular
matrix in all the animal species. This review will focus on the structural characteristics of the …

This book provides a comprehensive, up-to-date review of the structure, biology, and
molecular interactions of proteoglycans, consolidating into a single source research using …

Cell-surface proteoglycans participate in cell adhesion, growth-factor signalling, lipase
activity and anticoagulation. Until recently, only the roles of the glycosaminoglycan chains …

Because heparan sulfate proteoglycans mediate cell adhesion and control the activities of
numerous growth and motility factors, they play a critical role in regulating the metastatic …

Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …