Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet‐Induced Accumulation of Lipid in the Liver of ApoE−/− Mice

L Liu, Q Hu, H Wu, X Wang, C Gao… - Oxidative Medicine …, 2018 - Wiley Online Library
Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios
protect against liver damage in mice fed with a high‐fat diet (HFD). However, it is unclear …

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

T Shang, L Liu, J Zhou, M Zhang, Q Hu, M Fang… - Lipids in Health and …, 2017 - Springer
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-
alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not …

Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on liver lipid disorders in obese mice

W Liu, M Zhu, M Gong, W Zheng, X Zeng, Q Zheng, X Li… - Nutrients, 2023 - mdpi.com
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …

Different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high-fat diet-induced non-alcoholic fatty liver disease in mice

N Suzuki-Kemuriyama, T Matsuzaka, M Kuba, H Ohno… - PloS one, 2016 - journals.plos.org
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,
can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver …

Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa …

L Hong, P Zahradka, L Cordero-Monroy, B Wright… - Nutrients, 2019 - mdpi.com
Hepatic steatosis, an early stage of non-alcoholic fatty liver disease, is commonly present in
obesity and type 2 diabetes, and is associated with reduced hepatic omega-3 …

High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) …

F Echeverría, R Valenzuela, A Bustamante… - Food & Function, 2019 - pubs.rsc.org
High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain
polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial …

Different ratios of DHA/EPA reverses insulin resistance by improving adipocyte dysfunction and lipid disorders in HFD-induced IR mice

S Yu, Q Xie, W Tan, M Hu, G Xu, X Zhang, G Xie… - Food & Function, 2023 - pubs.rsc.org
Objective: Insulin resistance (IR) is linked to the development of diabetes, non-alcoholic fatty
liver disease (NAFLD), and cardiovascular disease (CVDs). Docosahexaenoic acid (DHA) …

Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

NK Soni, I Nookaew, AS Sandberg… - Lipids in health and …, 2015 - Springer
Background Low hepatic content of n-3 PUFA has been associated with NAFLD in humans.
Whether this is associated with reduced dietary intake or increased turnover of these FA is …

N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis

R Valenzuela, A Espinosa, D González-Mañán… - 2012 - journals.plos.org
Omega-3 (n-3) long-chain polyunsaturated fatty acids (n-3 LCPUFA) are associated with
several physiological functions, suggesting that their administration may prevent non …

Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat …

S Watanabe, K Tsuneyama - The Journal of Toxicological Sciences, 2013 - jstage.jst.go.jp
The administration of a sodium cholate-supplemented high-fat (CAHF) diet in mice induced
the predominant accumulation of cholesterol esters (CE) in the liver and biochemical and …