Lessons along the critical path: developing vaccines against human helminths

DJ Diemert, ME Bottazzi, J Plieskatt, PJ Hotez… - Trends in …, 2018 - cell.com
Helminthic parasites are important targets for vaccine research as they infect an estimated 1
billion people worldwide. Despite significant progress in the discovery of defined antigens …

Identifying novel candidates and configurations for human helminth vaccines

RM Maizels - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: Human infections with helminth worm parasites are extraordinarily prevalent
across tropical and subtropical parts of the world, and control relies primarily on drugs that …

Promising technologies in the field of helminth vaccines

DJ Perera, M Ndao - Frontiers in immunology, 2021 - frontiersin.org
Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

Vaccination against helminth parasites‐the ultimate challenge for vaccinologists?

RM Maizels, MJ Holland, FH Falcone… - Immunological …, 1999 - Wiley Online Library
Helminths are multicellular pathogens which infect vast numbers of human and animal
hosts, causing widspread chronic disease and morbidity, Vaccination against these …

Vaccination against helminth parasite infections

JP Hewitson, RM Maizels - Expert review of vaccines, 2014 - Taylor & Francis
Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …

Human anthelminthic vaccines: Rationale and challenges

PJ Hotez, U Strych, S Lustigman, ME Bottazzi - Vaccine, 2016 - Elsevier
Helminth infections are the most common afflictions of humankind, affecting almost every
single person living in profound poverty. Through mass drug administration (MDA) we have …

How to train your myeloid cells: a way forward for helminth vaccines?

R Doolan, N Putananickal, L Tritten… - Frontiers in …, 2023 - frontiersin.org
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no
vaccine is currently available for humans, the current strategy for elimination as a public …

Advances in helminth immunology: optimism for future vaccine design?

NL Harris - Trends in parasitology, 2011 - cell.com
Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate
with disease morbidity and children generally harbor the largest numbers. The majority of …

[图书][B] Parasitic helminths: targets, screens, drugs and vaccines

PM Selzer - 2012 - books.google.com
This third volume in the successful'Drug Discovery in Infectious Diseases' series is the first to
deal with drug discovery in helminthic infections in human and animals. The result is a broad …

Control of Important Helminthic Infections: VaccineDevelopment as Part of the Solution

R Bergquist, S Lustigman - Advances in parasitology, 2010 - Elsevier
Among the tools available for the control of helminth infections, chemotherapy has come to
totally dominate the field. In the veterinary field, development of drug resistance has …