There are many disorders of pyrimidine metabolism and those that involve an alteration in
uridine metabolism have neurological and systemic effects, which provide insights into the …

In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy
metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives …

Uridine is a pyrimidine nucleoside that plays a crucial role in synthesis of RNA, glycogen,
and biomembrane. In humans, uridine is present in plasma in considerably higher quantities …

Uracil nucleotides (ie, UTP and UDP) have been known for years as fundamental
intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether …

Uridine, a pyrimidine nucleoside essential for the synthesis of RNA and bio-membranes, is a
crucial element in the regulation of normal physiological processes as well as pathological …

Increasing evidence for receptors for uracil nucleotides has focused interest on specific
signalling mechanisms involving UTP and UDP. At least three metabotropic P2 receptors …

The biosynthesis of purines and pyrimidines is stringently regulated and coordinated by
feedback mechanisms that ensure their production in quantities and at times appropriate to …

Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside
analogs that are being investigated for possible use in chemotherapy of cancer. We have …

The growing evidence of the involvement of purine compounds in signaling, of nucleotide
imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light …