Amorphous solid dispersion (ASD) is a preparation widely used for improving the solubility
and low oral absorbability of poorly water-soluble drugs, but the quantitative analysis of its …

Amorphous solid dispersions (ASDs) are of great interest as enabling formulations because
of their ability to increase the bioavailability of poorly soluble drugs. However, the dissolution …

In spite of the fact that spray drying is widely applied for the formulation of amorphous solid
dispersions (ASDs), the influence of the solvent on the physical properties of the ASDs is still …

Amorphous solid dispersions (ASD) are intended to improve the bioavailability of poorly
water-soluble active pharmaceutical ingredients. However, the development of long-term …

Amorphous solid dispersions (ASDs) are a well-documented formulation approach to
improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However …

Abstract Hot-melt-extrusion (HME) is an enabling technology used for poorly soluble active
pharmaceutical ingredients (APIs) to increase the bioavailability by embedding the drug in a …

The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …

The evaluation of drug–polymer miscibility in the early phase of drug development is
essential to ensure successful amorphous solid dispersion (ASD) manufacturing. This work …

Amorphous solid dispersions (ASDs) can phase separate in the gel phase during
dissolution, lowering the chemical potential and thus the driving force for drug release. The …

Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying
low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with …