Targeting Carboxylesterase 2 Activity for Predicting and Improving Response to Pancreatic Cancer Treatment
K Kailass - 2023 - search.proquest.com
Pancreatic ductal adenocarcinoma is an aggressive form of cancer, with low patient survival
rates. Irinotecan, a key chemotherapeutic drug, is activated by carboxylesterase 2, which …
rates. Irinotecan, a key chemotherapeutic drug, is activated by carboxylesterase 2, which …
Carboxylesterase 2 as a determinant of response to irinotecan and neoadjuvant FOLFIRINOX therapy in pancreatic ductal adenocarcinoma
M Capello, M Lee, H Wang, I Babel… - Journal of the …, 2015 - academic.oup.com
Abstract Background: Serine hydrolases (SHs) are among the largest classes of enzymes in
humans and play crucial role in many pathophysiological processes of cancer. We have …
humans and play crucial role in many pathophysiological processes of cancer. We have …
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation
K Kailass, D Casalena, L Jenane… - Journal of medicinal …, 2024 - ACS Publications
As the primary enzyme responsible for the activatable conversion of Irinotecan (CPT-11) to
SN-38, carboxylesterase 2 (CES2) is a significant predictive biomarker toward CPT-11 …
SN-38, carboxylesterase 2 (CES2) is a significant predictive biomarker toward CPT-11 …
[HTML][HTML] Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor
Irinotecan-based therapy is a common treatment for pancreatic cancer. To elicit its
anticancer activity, the drug requires first the hydrolysis action of the enzyme human …
anticancer activity, the drug requires first the hydrolysis action of the enzyme human …
Determination of carboxylesterase 2 by fluorescence probe to guide pancreatic adenocarcinoma profiling
M Zhang, P Li, F Hai, Y Jia - Chemical Physics Letters, 2021 - Elsevier
Carboxylesterase 2 as a critical hydrolase, current studies are limited to its role in prodrug
metabolism while functional studies found that pancreatic adenocarcinoma (PAAD) is …
metabolism while functional studies found that pancreatic adenocarcinoma (PAAD) is …
[HTML][HTML] CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
Objective Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2)
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
[PDF][PDF] CES2 sustains HNF4a expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
Y Chen, M Capello, MVR Perez, JV Vykoukal, D Roife… - 2021 - researchgate.net
Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2)
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
CES2 Expression in pancreatic adenocarcinoma is predictive of response to irinotecan and is associated with type 2 diabetes
M Capello, JF Fahrmann, MV Rios Perez… - JCO Precision …, 2020 - ascopubs.org
PURPOSE The combination chemotherapy of fluorouracil, leucovorin, irinotecan, and
oxaliplatin (FOLFIRINOX) has provided clinically meaningful improvement for pancreatic …
oxaliplatin (FOLFIRINOX) has provided clinically meaningful improvement for pancreatic …
Two-photon photodynamic therapy targeting cancers with low carboxylesterase 2 activity guided by ratiometric fluorescence
Human carboxylesterase 2 (hCES2) converts anticancer prodrugs, such as irinotecan, into
their active metabolites via phase I drug metabolism. Owing to interindividual variability …
their active metabolites via phase I drug metabolism. Owing to interindividual variability …
Carboxylesterase-2-selective two-photon ratiometric probe reveals decreased carboxylesterase-2 activity in breast cancer cells
SJ Park, YJ Kim, JS Kang, IY Kim, KS Choi… - Analytical …, 2018 - ACS Publications
Human carboxylesterase-2 (CE2) is a carboxylesterase that catalyzes the hydrolysis of
endogenous and exogenous substrates. Abnormal CE2 levels are associated with various …
endogenous and exogenous substrates. Abnormal CE2 levels are associated with various …