Abstract The Systolic Hypertension in the Elderly Program (SHEP) is a randomized, blinded
test of the efficacy of antihypertensive drug treatment. In a large feasibility trial, 551 men and …

Context In the Systolic Hypertension in the Elderly Program (SHEP) trial, conducted between
1985 and 1990, antihypertensive therapy with chlorthalidone-based stepped-care therapy …

The Systolic Hypertension in the Elderly Program (SHEP) is a randomized double-blind
placebo-controlled trial to determine if antihypertensive treatment of isolated systolic …

Background Previous studies often of short duration have raised concerns that
antihypertensive therapy with diuretics and β-blockers adversely alters levels of other …

Context.—Heart failure is often preceded by isolated systolic hypertension, but the
effectiveness of antihypertensive treatment in preventing heart failure is not known …

The pilot study of the Systolic Hypertension in the Elderly Program was a randomized,
double-blind, placebo-controlled trial of drug therapy for isolated systolic hypertension. It …

We examined the association of orthostatic hypertension with all-cause mortality in the
active treatment and placebo randomized groups of the Systolic Hypertension in the Elderly …

Isolated systolic hypertension occurs with increased prevalence in the elderly population. It
is characterized by reduced vascular compliance, often combined with increased peripheral …

In a double-blind randomized study, we evaluated the effects of 25 mg vs 50 mg of
hydrochlorothiazide in 51 elderly patients (aged 68.9+-7.0 years) with isolated systolic …

Systolic hypertension is a major public health issue in the elderly and is often under-
recognized and under-treated. The concept that systolic blood pressure increases with age …