Background Recent renewed emphasis on the eradication of malaria has highlighted the
need for more tools with which to achieve this ambitious goal. One high priority area is the …

Drugs that kill or inhibit the sexual stages of Plasmodium in order to prevent transmission
are important components of malaria control programmes. Reducing gametocyte carriage is …

Background Plasmodium falciparum gametocytes, specifically mature stages, are the only
stage in man transmissible to the mosquito vector responsible for malaria transmission. Anti …

The discovery of new antimalarial drugs able to target both the asexual and gametocyte
stages of Plasmodium falciparum is critical to the success of the malaria eradication …

The discovery of new chemical starting points with the ability to inhibit Plasmodium
falciparum sexual stages, and therefore block the disease transmission, is urgently required …

Recent success in the global reduction campaign against malaria has resulted in the
possibility that it may be feasible to drastically reduce or even eradicate malaria even …

Background Malaria elimination/eradication campaigns emphasize interruption of parasite
transmission as a priority strategy. Screening for new drugs and vaccines against …

Although the illness malaria is caused by the asexual blood stages, the presence of
gametocytes is directly responsible for the infection of the vector Anopheles, thus …

Objectives As most available antimalarial drugs are ineffective against the Plasmodium
falciparum transmission stages, new drugs against the parasite's gametocytes are urgently …

Background Current anti-malarial drugs have been selected on the basis of their activity
against the symptom-causing asexual blood stage of the parasite. Which of these drugs also …