Regional differences in the effect of guanine nucleotides on agonist and antagonist binding to adenosine A1-receptors in rat brain, as revealed by autoradiography

J Fastbom, BB Fredholm - Neuroscience, 1990 - Elsevier
The effect of increasing doses of GTP on agonist and antagonist binding to adenosine A1-
receptors in different regions of rat brain was studied by autoradiography. A high …

Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S] …

A Lorenzen, M Fuss, H Vogt, U Schwabe - Molecular Pharmacology, 1993 - ASPET
Signal transduction by A1 adenosine receptors was investigated by measuring the
modulation by adenosine agonists of guanosine-5'-O-(3-[35S] thio) triphosphate ([35S] GTP …

[引用][C] Regional differences in the GTP‐dependence of adenosine receptor binding in rat brain?

J Fastbom, BB Fredholm - Acta physiologica scandinavica, 1987 - Wiley Online Library
With autoradiographic techniques adenosine Ar-receptors in rat brain were shown to be
heterogeneously distributed and to be concentrated to some brain regions, such as the …

GTP differentially affects antagonist radioligand binding to adenosine A1 and A2A receptors in human brain

B Kull, P Svenningsson, H Hall, BB Fredholm - Neuropharmacology, 2000 - Elsevier
The effect of guanosine triphosphate (GTP) on the interaction of antagonists with human
adenosine A1 and A2A receptors was studied using whole-hemisphere sections from …

[PDF][PDF] Guanine nucleotide and cation regulation of the binding of [3H] cyclohexyladenosine and [3H] diethylphenylxanthine to adenosine A1 receptors in brain …

RR Goodman, MJ Cooper, M Gavish… - Molecular …, 1982 - Citeseer
Guamne nucleotides, divalent cations, and sodium differentially regulate agonist and
antagonist binding to adenosine A, receptors in brain membranes. Guanine nucleotides …

Regulation of agonist binding to A2A adenosine receptors: effects of guanine nucleotides (GDP [S] and GTP [S]) and Mg2+ ion

MR Mazzoni, C Martini, A Lucacchini - Biochimica et Biophysica Acta (BBA) …, 1993 - Elsevier
Adenosine acts as a neuromodulator through at least two receptor subtypes, A 1 and A 2. A
2 receptors have been further divided into A 2A (high agonist affinity) and A 2B (low agonist …

A1 Adenosine Receptor‐G Protein Coupling in Bovine Brain Membranes: Effects of Guanine Nucleotides, Salt, and Solubilization

GL Stiles - Journal of neurochemistry, 1988 - Wiley Online Library
The effects of guanine nucleotides, NaCl, and solubilization on the interaction of antagonists
and agonists with the A1 adenosine receptor of bovine brain membranes were studied using …

Differences in the GTP-regulation of membrane-bound and solubilized A1-adenosine receptors

M Ströher, C Nanoff, W Schütz - Naunyn-Schmiedeberg's archives of …, 1989 - Springer
Summary Using [3 H] 8-cyclopentyl-1, 3-dipropylxanthine (DPCPX), a 3 H-labeled A 1-
selective adenosine antagonist with high affinity and extremely low non-specific binding, it …

Guanine Nucleotide Effects on 8‐Cyclopentyl‐1,3‐[3H]Dipropylxanthine Binding to Membrane‐Bound and Solubilized A1 Adenosine Receptors of Rat Brain

KN Klotz, R Keil, FJ Zimmer… - Journal of …, 1990 - Wiley Online Library
The effects of guanine nucleotides on binding of 8‐cyclopentyl‐1, 3‐[3H] dipropylxanthine
([3H] DPCPX), a highly selective A1 adenosine receptor antagonist, have been investigated …

Solubilization of A1 adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high‐ and low‐affinity …

V Casadó, C Canti, J Mallol, EI Canela… - Journal of …, 1990 - Wiley Online Library
The present solubilization strategy recognizes the important role of detergent cocktails in the
solubilization and subsequent stability of adenosine A1, receptors from pig brain cortical …