Highlights•siRNAs are effective and powerful gene tools in cancer therapy.•Smart
nanocarriers can tune the pharmacokinetics and therapy efficacy of siRNAs.•All-in-one …

Micelle-based siRNA carriers (“micelleplexes”) were prepared from the A− B− C triblock
copolymer poly (ethylene glycol)-poly (n-butyl acrylate)-poly (2-(dimethylamino) ethyl …

Gene silencing through RNA interference (RNAi) has emerged as a potential strategy in
manipulating cancer causing genes by complementary base-pairing mechanism. Small …

Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …

MicroRNAs (miRNAs) regulate multiple molecular pathways vital for the hallmarks of cancer
with a high degree of biochemical specificity and potency. By restoring tumor suppressive …

Small-interfering RNA (siRNA) is both a powerful tool in research and a promising
therapeutic platform to modulate expression of disease-related genes. Malignant tumors are …

RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism,
where non-coding, double-stranded RNA molecules interfere with the expression of certain …

ABSTRACT Introduction: Small interfering RNA (siRNA) is an effective method for regulating
the expression of proteins, even “undruggable” ones that are nearly impossible to target …

Advances in nanotechnology have provided powerful and efficient tools in the development
of cancer diagnosis and therapy. There are numerous nanocarriers that are currently …