Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy
Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …
Nanomedicine based approaches for the delivery of siRNA in cancer
B Ozpolat, AK Sood… - Journal of internal …, 2010 - Wiley Online Library
Small interfering RNA (siRNA) technology holds great promise as a therapeutic intervention
for targeted gene silencing in cancer and other diseases. However, in vivo systemic delivery …
for targeted gene silencing in cancer and other diseases. However, in vivo systemic delivery …
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery
O Taratula, OB Garbuzenko, P Kirkpatrick… - Journal of Controlled …, 2009 - Elsevier
Low penetration ability of Small Interfering RNA (siRNA) through the cellular plasma
membrane combined with its limited stability in blood, limits the effectiveness of the systemic …
membrane combined with its limited stability in blood, limits the effectiveness of the systemic …
Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems
S Mirzaei, MK Mahabady, A Zabolian, A Abbaspour… - Life Sciences, 2021 - Elsevier
Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …
[HTML][HTML] Delivery of therapeutic miRNA using polymer-based formulation
MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in many cellular
processes such as development, proliferation, differentiation, and apoptosis. For this reason …
processes such as development, proliferation, differentiation, and apoptosis. For this reason …
miRNA nanotherapeutics for cancer
Highlights•MicroRNAs play a major role in cancer.•Several clinical trials with microRNA are
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …
[HTML][HTML] Oral delivery of RNAi for cancer therapy
Cancer is a major health concern worldwide and is still in a continuous surge of seeking for
effective treatments. Since the discovery of RNAi and their mechanism of action, it has …
effective treatments. Since the discovery of RNAi and their mechanism of action, it has …
Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines
Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad
therapeutic potentials toward various diseases including viral infections and cancer. With …
therapeutic potentials toward various diseases including viral infections and cancer. With …
[HTML][HTML] Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer
M Ashrafizadeh, K Hushmandi, E Rahmani Moghadam… - Bioengineering, 2020 - mdpi.com
Prostate cancer (PCa) accounts for a high number of deaths in males with no available
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …
[HTML][HTML] Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
The selective delivery of small interfering RNA (siRNA) to metastatic tumors remains a
challenging task. We have developed a nanoparticle (NP) formulation composed of siRNA …
challenging task. We have developed a nanoparticle (NP) formulation composed of siRNA …