Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …

Simple Summary The discovery of microRNAs has revolutionized the world of science and
opened up new opportunities in cancer treatment. miRNA dysregulation plays a crucial role …

Low penetration ability of Small Interfering RNA (siRNA) through the cellular plasma
membrane combined with its limited stability in blood, limits the effectiveness of the systemic …

Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …

MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in many cellular
processes such as development, proliferation, differentiation, and apoptosis. For this reason …

Cancer is a major health concern worldwide and is still in a continuous surge of seeking for
effective treatments. Since the discovery of RNAi and their mechanism of action, it has …

The selective delivery of small interfering RNA (siRNA) to metastatic tumors remains a
challenging task. We have developed a nanoparticle (NP) formulation composed of siRNA …

Gene therapy is a promising strategy to treat various genetic and acquired diseases. Small
interfering RNA (siRNA) is a revolutionary tool for gene therapy and the analysis of gene …

Highlights•MicroRNAs play a major role in cancer.•Several clinical trials with microRNA are
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …

Prostate cancer (PCa) accounts for a high number of deaths in males with no available
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …